Rede Lamartine - Computer Models Could Allow Researchers to Better Understand, Predict Adverse Drug Reactions

New computer models from North Carolina State
University show how a variant of a common
protein involved in human immune response binds
to the antiviral drug abacavir, causing a severe
life-threatening reaction known as the abacavir
hypersensitivity syndrome (AHS). The work has
implications for predicting severe adverse
reactions caused by existing drugs and future
drug candidates in subpopulations of patients.
Abacavir is a common anti-HIV drug. However, it
is associated with severe allergic reactions in a
fraction (5-8 percent) of patients who take it.
Previous research determined that this response
occurs in patients with a particular variant of a
human leukocyte antigen (HLA) known as HLA-
B*57:01.

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